Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a joint strike on an hidden munitions depot in Syrian territory operated by the IS group, per a report from the UK's MoD.
The site, pinpointed through intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountains just north of the historic site of Palmyra in the heart of Syria.
"The RAF jets utilized precision-guided Paveway IV munitions to strike a series of entry passages providing entry to the depot... preliminary assessments are that the objective was successfully hit," the ministry announced.
There was no indication of any civilian casualties in the operation conducted Saturday night and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
The Islamic State group - referred to as ISIS - enforced jihadist rule over significant areas in both Syria and Iraq until 2019.
"This operation underscores our UK leadership, and determination to operate in unison with allied nations, to eradicate any re-emergence of IS and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief John Healey stated.
British military aircraft have conducted patrols over Syrian airspace to "deter any attempted comeback" of the group after its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank the personnel of the UK armed forces who took part in this operation for their expertise and their courage," he said. "Including them were numerous UK service members stationed over the holidays. This operation, to eliminate militants who pose a risk to our safety, highlights how UK forces are always on standby, throughout the year, ensuring Britain's security within its borders and influential overseas."
During December, the United States armed forces carried out what it described as a "major assault" on IS targets in the country, after an ambush killed two American soldiers and a civilian linguist in Palmyra.
The U.N. estimates IS still has an estimated 5,000 to 7,000 militants in Iraq and Syria.